β2-Adrenoceptor Agonist Clenbuterol Causes NGF Expression and Neuroprotection
نویسندگان
چکیده
منابع مشابه
β2-Adrenoceptor polymorphism and bronchoprotective sensitivity with regular short- and long-acting β2-agonist therapy
The aim of the present study was to investigate bronchoprotective sensitivity in patients receiving regular treatment with shortand long-acting β2-agonists and to evaluate any possible association with genetic polymorphism. Thirty-eight patients with stable mild to moderate asthma and receiving inhaled corticosteroids were randomized in a parallel group, double-blind, double-dummy fashion to re...
متن کاملThe long-acting β2-adrenoceptor agonist olodaterol attenuates pulmonary inflammation
BACKGROUND AND PURPOSE β2 -adrenoceptor agonists are widely used in the management of obstructive airway diseases. Besides their bronchodilatory effect, several studies suggest inhibitory effects on various aspects of inflammation. The aim of our study was to determine the efficacy of the long-acting β2 -adrenoceptor agonist olodaterol to inhibit pulmonary inflammation and to elucidate mechanis...
متن کاملThe β2-adrenoceptor agonist formoterol stimulates mitochondrial biogenesis.
Mitochondrial dysfunction is a common mediator of disease and organ injury. Although recent studies show that inducing mitochondrial biogenesis (MB) stimulates cell repair and regeneration, only a limited number of chemicals are known to induce MB. To examine the impact of the β-adrenoceptor (β-AR) signaling pathway on MB, primary renal proximal tubule cells (RPTC) and adult feline cardiomyocyt...
متن کاملPolymorphism of the β2-adrenoceptor and the response to long-term β2-agonist therapy in asthma
In 1990 we reported a randomized controlled trial in which the administration of regular inhaled β2-agonist therapy was associated with a deterioration in asthma control in a majority of subjects when compared to as-required β-agonist treatment [1]. There were more asthma exacerbations, reductions in the forced expiratory volume in one second (FEV1) and morning peak expiratory flow rates (PEFRs...
متن کاملEffects of Clenbuterol, a β2-Adrenergic Agonist, on Sizes of Masseter, Temporalis, Digastric, and Tongue muscles
We compared the hypertrophic effects of clenbuterol, a β₂-adrenergic agonist, on the masseter, digastric, and temporalis with those on the tongue, tibialis anterior, soleus, diaphragm, and heart. The weights of masseter, digastric and temporalis in the clenbuterol group were 36 ~ 56% greater than those in the control group, whereas those of the tibialis anterior, diaphragm, and heart weights in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: CNS Drug Reviews
سال: 2006
ISSN: 1080-563X
DOI: 10.1111/j.1527-3458.1999.tb00110.x